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Due to a significant incidence of GI side effects and diarrhea, most practitioners now use a shorter loading period with lower doses or initiate treatment at mg/day with no loading dose,. The dose may be reduced to 10mg daily if not tolerated at the 20 mg dose. Its efficacy is similar to methotrexate in terms of signs and symptoms, and is a viable alternative to patients who have failed or are intolerant to methotrexate. Leflunomide has been demonstrated to slow radiographic progression.

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The Canaanite deities were believed to have control over various aspects of life, such as fertility, agriculture, war, and the weather. Their worship involved elaborate rituals and sacrifices, and they were often depicted in elaborate artwork and sculpture. The 12 gods of Mount Olympus were the most important deities in ancient Greece. With their all-too-human qualities in Greek mythology, the Olympian gods were capable of displaying great kindness and dishing out terrible punishments.